Narine has been particularly brutal against the Bangalore franchise in recent times, with his last three innings yielding 138 runs from just 53 balls.
Eventually, Knight Riders reached the target with Karthik finishing unbeaten on 35 off 29 balls.
Narine punishes RCB - again: Virat Kohli must get sick of watching Sunil Narine at the crease, with the Trinadian blasting a vital 50 from just 19 balls to give Kolkata the flawless platform to launch from. The four overseas are Lynn, Narine, Russell and Johnson.
Practice of both teams were hampered due to rain, before the game.
The visitors lost Quinton De Kock (4) early, the South African wicketkeeper-batsman trying to reverse sweep Piyush Chawla (1/31) and picking out Vinay Kumar at short third man.
Virat Kohli has taken regular breaks over the past few months to keep himself operating at optimum level and the Bangalore captain said he has nearly reached that level at the start of this edition of the IPL.
However, Rana's special show denied RCB a huge total.
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Before this game, Rana had only four T20 wickets to his name. Happy start for Karthik as a captain. Kohli is clear at [3.4] but AB De Villiers, after issues with injury, looked somewhere close to his best towards the end of the South African global season and he's the pick at a generous [4.3]. But two balls later, the momentum had completely shifted.
Mitchell Starc has been ruled out of the tournament with a tibial bone stress fracture in his right leg, and the Knight Riders coach Jacques Kallis has pinned his faith on Tom Curran, the bowling allrounder from England, to fill in ably. The outfit in the purple and gold strode out with their new skipper Dinesh Karthik and proved to everyone that they were not here to make up the numbers.
Virat Kohli too yorked himself the very next delivery to give all the advantage to the hosts as they posted 176 runs in their 20 overs courtesy Mandeep Singh who hit few sixes at the death.
It wasn't unfamiliar territory for RCB when Narine walked out with Chris Lynn for the chase.
So you'd think RCB would have had new plans for the Trinidadian, but he seemed to take them by surprise once again.
Spin returned for the fifth over, this time in the shape of Washington Sundar, but even the Powerplay specialist wasn't spared.
In response, Sunil Narine got his team off to an absolutely blazing start and whacked 50 off just 19 balls attacking all the bowlers that came his way.
Lynn may also be skinny at [3.3] but he's the key wicket and could deliver the profit whether he ruins the match tip or not.