On Griezmann, Atletico coach Diego Simeone said: "He is a great player, he did not have a good start to the season and he knows it and it is not easy to reinvent himself in the way he did in November, December". Ronaldo's goal against Atletico was his 20th in his last 10 games in all competitions.
Saul bent a shot narrowly wide for Atletico and Real, who brought on Luka Modric and Isco for Mateo Kovacic and Asensio, nearly snatched a late, late victor but Oblak made an excellent save from Sergio Ramos' free kick.
Real Madrid welcome Juventus to the Santiago Bernabeu on Wednesday for the second leg of their Champions League quarter-final.
Ronaldo scored the first as Bale's hanging cross was misjudged by Lucas Hernandez at the back post, allowing the striker to volley in his 23rd league goal of the season. It took Ronaldo to 22 goals in 30 career games vs Atletico and was also the 500th by anyone in a derbi.
Guardiola plays down Man City clinching title against Man Utd
City have often been unfairly cast as a team of mercenaries, an image that was ended by Pablo Zabaleta's departure in the summer. Despite United's defensive approach, City were able to breach them at Old Trafford and pick up the momentum a year ago .
The 24-year-old has made 27 appearances in the league this season, fashioning three goals.
Atleti were then on the charge and Koke should have put them ahead before the withdrawals of Ronaldo and Diego Costa for either side saw the offensive threat subside - much to the delight of those watching on in Catalonia. He played in Vitolo and then, after Navas had denied the winger, the French global cleverly followed to slide home.
Ernesto Valverde's team are are now 11 points clear with just seven games left to play.
Atletico have finished as the capital's top team just once in the last 21 years - when they won title in 2013-14 - but look set to do so again.
"We have to do our work well and play a complete game".