Nadal quickly wrapped up the final two points needed to secure the second set and level the match before the world No 1 maintained his ascendancy during the third set with two breaks of serve to move ahead in the match, after saving four break points when he served out.
The Spaniard saw his 37-set winning streak at Roland Garros come to an end against the Argentine on Thursday before improving his level after a rain interval, only for a second interruption to end the day's play, with Nadal serving for the second set.
A rescued break point in the opening game of the third was further evidence of Marterer's fortitude and Nadal was guilty of losing focus, smashing a routine forehand into the tramlines to go 3-1 down. World number one Nadal, who made 14 unforced errors and struck just four winners in the opener, has only lost two French Open matches in his career.
They will return on Thursday morning.
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Head coach Tyronn Lue said the Cavaliers can't win without being more physical, a point James agreed with. "He made shots. The Cavaliers were one Durant three-pointer in the final minute away from possibly making the series in 2017 2-1.
Kasatkina raced away with the last three games of the tie which had been halted at 3-3 in the second set late Sunday because of bad light.
However, when the players came back on after a delay of nearly an hour Nadal immediately broke back to level the second set.
Kasatkina will face US Open victor Sloane Stephens for a place in the semifinals.
Sharapova, playing at Roland Garros for the first time since 2015, suffered her most one-sided defeat at the Slams since a 6-3, 6-0 loss to Victoria Azarenka in the 2012 Australian Open final.
"I was up against a great player so I had to make sure I brought my best tennis".