For Mexico, the prospect of facing mighty Brazil with everything on the line is "the ideal scenario", the 31-year-old Guardado said.
The Costa Rican players have been heavily criticized back home and will hope to turn the pages to give their people something to cheer about.
Questions were raised after Renato Augusto, Fred, Danilo, Douglas Costa and Marcelo all got hit by injuries before and during the World Cup. This might cause big problems against a team like Brazil.
"We can take the pressure, we are a balanced team and we have replacement who can come in, which is important", said the Brazil's head coach Tite.
"It is still too early to make an accurate diagnosis", said Dr Lasmar via Goal.
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Neymar's goal from inside the six-yard area made it 2-0 for five-time winners Brazil on 22 June. "It's all under control".
Though Mexico have never won against Brazil in a FIFA World Cup, Guardado said that El Tri was not intimidated by next Monday evening's (Tuesday morning AEST) match.
"Thank God it wasn't anything serious", Marcelo said on Instagram.
Costa and Danilo, who was nursing a hip injury, did not travel with the rest of the squad for the match against Serbia in Moscow.
The other group game is between Switzerland and Costa Rica.