Although De Bruyne, whose wife gave birth to their second child on Wednesday, does not require an operation, he will fly to Barcelona to see specialist Dr Ramon Cagut.
"We are a stronger team with Kevin than without him".
De Bruyne missed the majority of the opening two months of the season with a knee problem, but the 27-year-old's outing against the Cottagers had represented his fourth appearance since making a comeback in October.
"He's being checked with the doctors so I don't know right now (how he is)", he said.
He is also expected to be ruled out of this Sunday's league game against Southampton, the Champions League tie at home to Shakhtar Donetsk three days later and matches against West Ham, Lyon and Bournemouth. "We insist we want him, but it's the agent, him, family, they decide". He understands the way we want to play.
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"Yesterday he came back in many, many things". Raheem Sterling and Sergio Aguero were among those who didn't make it off the bench.
Manchester City midfielder Kevin De Bruyne is set to miss the Manchester derby but the full extent of his latest injury setback will not be known until he has further tests, sources have told ESPN FC.
"I think today, Kevin is back", Guardiola said.
"Today again he was involved with everything offensively and defensively, so hopefully what happened in the last minutes is not serious".